What are they and can they be removed?

Red spots on gold coins is a well know issue. It used to be thought that these were copper spots in alloyed coins. Well, 2008 Buffalos are essentially pure gold, yet they also frequently suffer from these spots. I have one in my possession with a spot near the top of the head (see pic). My questions:

1. How do these spots affect grading?

2. Can they be removed?

3. Does anyone have any experience with NCS removing them?

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